Reactome | ACY1:Zn2+ dimer deacetylates NAC to L-Cys

Schema > Reaction > Entries

ACY1:Zn2+ dimer deacetylates NAC to L-Cys Show undefined attributes

catalystActivity	[CatalystActivity:10789902] aminoacylase activity of ACY1:Zn2+ dimer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10819178
displayName	ACY1:Zn2+ dimer deacetylates NAC to L-Cys
eventOf	[Pathway:R-GGA-9753281] Paracetamol ADME - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-GGA-174367] GCL ligates L-Glu to L-Cys - Gallus gallus
inferredFrom	[Reaction:R-HSA-9753944] ACY1:Zn2+ dimer deacetylates NAC to L-Cys - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-9753926] NAC [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	ACY1:Zn2+ dimer deacetylates NAC to L-Cys
output	[SimpleEntity:R-ALL-9717939] acetate [cytosol] [SimpleEntity:R-ALL-111707] L-Cys [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-9753944
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-9753281] Paracetamol ADME
(precedingEvent)	[Reaction:R-GGA-174367] GCL ligates L-Glu to L-Cys
(inferredTo)	[Reaction:R-HSA-9753944] ACY1:Zn2+ dimer deacetylates NAC to L-Cys

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