Reactome | Active ALK phosphorylates IRS1

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Active ALK phosphorylates IRS1 Show undefined attributes

catalystActivity	[CatalystActivity:10817964] protein tyrosine kinase activity of Active ALK:IRS1 [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10817966
displayName	Active ALK phosphorylates IRS1
eventOf	[Pathway:R-GGA-201556] Signaling by ALK - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-9700168] Active ALK phosphorylates IRS1 - Homo sapiens
input	[Complex:R-GGA-9699993] Active ALK:IRS1 [plasma membrane] [SimpleEntity:R-ALL-113592] ATP [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Active ALK phosphorylates IRS1
output	[Complex:R-GGA-9699983] Active ALK:pY-IRS1 [plasma membrane] [SimpleEntity:R-ALL-29370] ADP [cytosol]
precedingEvent	[Reaction:R-GGA-9700156] Active ALK dimer binds IRS1 - Gallus gallus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-9700168
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-201556] Signaling by ALK
(inferredTo)	[Reaction:R-HSA-9700168] Active ALK phosphorylates IRS1

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