Reactome | HEXB cleaves the terminal GlcNAc from keratan sulfate

Schema > Reaction > Entries

HEXB cleaves the terminal GlcNAc from keratan sulfate Show undefined attributes

catalystActivity	[CatalystActivity:10816629] beta-N-acetylhexosaminidase activity of bHEXB [lysosomal lumen]
category	transition
compartment	[Compartment:161320] lysosomal lumen
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10816635
displayName	HEXB cleaves the terminal GlcNAc from keratan sulfate
eventOf	[Pathway:R-GGA-2022857] Keratan sulfate degradation - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-9638078] HEXB cleaves the terminal GlcNAc from keratan sulfate - Homo sapiens
input	[SimpleEntity:R-ALL-2105012] GlcNAc-Gal-GlcNAc(S)-Gal [lysosomal lumen] [SimpleEntity:R-ALL-1605715] H2O [lysosomal lumen]
isInDisease	false
isInferred	true
maxDepth	1
name	HEXB cleaves the terminal GlcNAc from keratan sulfate
output	[SimpleEntity:R-ALL-2105010] Gal-GlcNAc(S)-Gal [lysosomal lumen] [SimpleEntity:R-ALL-1678743] GlcNAc [lysosomal lumen]
precedingEvent	[Reaction:R-GGA-1638032] GNS:Ca2+ cleaves sulfate from GlcNAc-6-sulfate units of keratan sulfate - Gallus gallus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-9638078
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-2022857] Keratan sulfate degradation
(inferredTo)	[Reaction:R-HSA-9638078] HEXB cleaves the terminal GlcNAc from keratan sulfate

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