Reactome | IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3

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IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3 Show undefined attributes

catalystActivity	[CatalystActivity:10813816] transmembrane receptor protein tyrosine kinase activity of IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 [plasma membrane]
category	omitted
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10813818
displayName	IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3
eventOf	[Pathway:R-GGA-8854691] Interleukin-20 family signaling - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-GGA-8987104] IL20:IL20RA:JAK1:IL20RB:p?JAK2,p?JAK3 binds STAT3 - Gallus gallus
inferredFrom	[BlackBoxEvent:R-HSA-8987179] IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3 - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-GGA-8987246] IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3 JAK2, JAK3 are phosphorylated after IL20:IL20RA:JAK1:IL20RB:JAK2:JAK3 interaction JAK2, JAK3 are phosphorylated after IL20 IL20 receptor JAK2, JAK3 are phsophorylated after IL20 stimulus
output	2 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-GGA-8986978] IL20:IL20RA:JAK1:IL20RB:p-Y1007,Y1008-JAK2,p-JAK3 [plasma membrane]
precedingEvent	[BlackBoxEvent:R-GGA-8987220] IL20:IL20RA:JAK1:IL20RB binds JAK2,JAK3 - Gallus gallus
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:49591] Gallus gallus
stId	R-GGA-8987179
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-8854691] Interleukin-20 family signaling
(precedingEvent)	[BlackBoxEvent:R-GGA-8987104] IL20:IL20RA:JAK1:IL20RB:p?JAK2,p?JAK3 binds STAT3
(inferredTo)	[BlackBoxEvent:R-HSA-8987179] IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3

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