Reactome | IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3

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IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3 Show undefined attributes

catalystActivity	[CatalystActivity:10813798] transmembrane receptor protein tyrosine kinase activity of IL20:IL20RA:JAK1:IL20RB:p-Y1007,Y1008-JAK2,p-JAK3:STAT3 [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10813800
displayName	IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3
eventOf	[Pathway:R-GGA-8854691] Interleukin-20 family signaling - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-GGA-8987156] p-STAT3 dissociates from IL20:IL20RA:JAK1:IL20RB:p-Y1007,Y1008-JAK2,p-JAK3 - Gallus gallus
inferredFrom	[Reaction:R-HSA-8987141] IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3 - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-GGA-8987123] IL20:IL20RA:JAK1:IL20RB:p-Y1007,Y1008-JAK2,p-JAK3:STAT3 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-GGA-8987219] IL20:IL20RA:JAK1:IL20RB:p-Y1007,Y1008-JAK2,p-JAK3:p-STAT3 [plasma membrane]
precedingEvent	[BlackBoxEvent:R-GGA-8987104] IL20:IL20RA:JAK1:IL20RB:p?JAK2,p?JAK3 binds STAT3 - Gallus gallus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-8987141
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-8854691] Interleukin-20 family signaling
(precedingEvent)	[BlackBoxEvent:R-GGA-8987156] p-STAT3 dissociates from IL20:IL20RA:JAK1:IL20RB:p-Y1007,Y1008-JAK2,p-JAK3
(inferredTo)	[Reaction:R-HSA-8987141] IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3

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