Reactome | Phosphorylated FUNDC1 links damaged mitochondria to LC3

Schema > Reaction > Entries

Phosphorylated FUNDC1 links damaged mitochondria to LC3 Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10812914
displayName	Phosphorylated FUNDC1 links damaged mitochondria to LC3
eventOf	[Pathway:R-GGA-8934903] Receptor Mediated Mitophagy - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-GGA-8959571] LC3 binds the autophagosome membrane Atg5-Atg12 complex - Gallus gallus
inferredFrom	[Reaction:R-HSA-8959573] Phosphorylated FUNDC1 links damaged mitochondria to LC3 - Homo sapiens
input	[EntityWithAccessionedSequence:R-GGA-5205676] MAP1LC3A [cytosol] [EntityWithAccessionedSequence:R-GGA-8948140] phospho-FUNDC1 [mitochondrial outer membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Phosphorylated FUNDC1 links damaged mitochondria to LC3
output	[Complex:R-GGA-8959568] p-S17-FUNDC1:LC3 [mitochondrial outer membrane]
precedingEvent	[Reaction:R-GGA-8948146] FUNDC1 is phosphorylated by ULK1 at Ser17 - Gallus gallus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-8959573
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-8934903] Receptor Mediated Mitophagy
(precedingEvent)	[Reaction:R-GGA-8959571] LC3 binds the autophagosome membrane Atg5-Atg12 complex
(inferredTo)	[Reaction:R-HSA-8959573] Phosphorylated FUNDC1 links damaged mitochondria to LC3

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