Reactome | PLD6 dimer hydrolyses cardiolipin to PA and PG

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PLD6 dimer hydrolyses cardiolipin to PA and PG Show undefined attributes

catalystActivity	[CatalystActivity:10812610] cardiolipin phospholipase D activity of PLD6 dimer [mitochondrial outer membrane]
category	transition
compartment	[Compartment:17906] mitochondrial outer membrane [Compartment:17927] mitochondrial intermembrane space
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10812628
displayName	PLD6 dimer hydrolyses cardiolipin to PA and PG
eventOf	[Pathway:R-GGA-1483166] Synthesis of PA - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-8954398] PLD6 dimer hydrolyses cardiolipin to PA and PG - Homo sapiens
input	[SimpleEntity:R-ALL-8954419] cardiolipin [mitochondrial outer membrane] [SimpleEntity:R-ALL-189422] H2O [mitochondrial intermembrane space]
isInDisease	false
isInferred	true
maxDepth	1
name	PLD6 dimer hydrolyses cardiolipin to PA and PG
output	[SimpleEntity:R-ALL-1500590] PA [mitochondrial outer membrane] [SimpleEntity:R-ALL-8954401] PG [mitochondrial outer membrane]
regulatedBy	[PositiveRegulation:10812629] Positive regulation by 'MIGA complexes [mitochondrial outer membrane]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-8954398
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-1483166] Synthesis of PA
(inferredTo)	[Reaction:R-HSA-8954398] PLD6 dimer hydrolyses cardiolipin to PA and PG

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