Reactome | Regulation of PTEN localization

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Regulation of PTEN localization Show undefined attributes

created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10827981
displayName	Regulation of PTEN localization
eventOf	[Pathway:R-GGA-6807070] PTEN Regulation - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-GGA-6807106] PTEN undergoes monoubiquitination - Gallus gallus [BlackBoxEvent:R-GGA-6807105] Monoubiquitinated PTEN translocates to the nucleus - Gallus gallus [Reaction:R-GGA-6807118] USP7 deubiquitinates monoubiquitinated PTEN - Gallus gallus [Reaction:R-GGA-6807126] Deubiquitinated PTEN translocates to the cytosol - Gallus gallus
inferredFrom	[Pathway:R-HSA-8948747] Regulation of PTEN localization - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Regulation of PTEN localization
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49591] Gallus gallus
stId	R-GGA-8948747
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-6807070] PTEN Regulation
(inferredTo)	[Pathway:R-HSA-8948747] Regulation of PTEN localization

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