Reactome | MMP2, MMP9 cleave SCUBE3

Schema > Reaction > Entries

MMP2, MMP9 cleave SCUBE3 Show undefined attributes

catalystActivity	[CatalystActivity:10810874] metalloendopeptidase activity of MMP2, MMP9 [extracellular region]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10810876
displayName	MMP2, MMP9 cleave SCUBE3
eventOf	[Pathway:R-GGA-1474228] Degradation of the extracellular matrix - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-8943959] MMP2, MMP9 cleave SCUBE3 - Homo sapiens
input	[EntityWithAccessionedSequence:R-GGA-8943884] SCUBE3 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	MMP2, MMP9 cleave SCUBE3
output	[EntityWithAccessionedSequence:R-GGA-8943978] SCUBE3 [plasma membrane] [EntityWithAccessionedSequence:R-GGA-8943967] SCUBE3 [plasma membrane]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-8943959
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-1474228] Degradation of the extracellular matrix
(inferredTo)	[Reaction:R-HSA-8943959] MMP2, MMP9 cleave SCUBE3

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