Reactome | NTPDase4 hydrolyzes nucleoside diphosphates

Schema > Reaction > Entries

NTPDase4 hydrolyzes nucleoside diphosphates Show undefined attributes

catalystActivity	[CatalystActivity:10805371] nucleoside diphosphate phosphatase activity of NTPDase4:Ca2+ [Golgi membrane]
category	transition
compartment	[Compartment:17963] Golgi lumen [Compartment:20699] Golgi membrane
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10805373
displayName	NTPDase4 hydrolyzes nucleoside diphosphates
eventOf	[Pathway:R-GGA-8850843] Phosphate bond hydrolysis by NTPDase proteins - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-8851225] NTPDase4 hydrolyzes nucleoside diphosphates - Homo sapiens
input	[SimpleEntity:R-ALL-2022884] H2O [Golgi lumen] [DefinedSet:R-ALL-8851224] UDP,GDP,CDP,dTDP [Golgi lumen]
isInDisease	false
isInferred	true
maxDepth	1
name	NTPDase4 hydrolyzes nucleoside diphosphates UDP + H2O => UMP + phosphate + H(+) CDP + H2O => CMP + phosphate + H(+) GDP + H2O => GMP + phosphate + H(+) dTDP + H2O => dTMP + phosphate + H(+)
output	[SimpleEntity:R-ALL-425969] H+ [Golgi lumen] [SimpleEntity:R-ALL-8851226] Pi [Golgi lumen] [DefinedSet:R-ALL-8851227] UMP,GMP,CMP,dTMP [Golgi lumen]
precedingEvent	[Reaction:R-GGA-8851234] NTPDase4 hydrolyzes nucleoside triphosphates - Gallus gallus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-8851225
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-8850843] Phosphate bond hydrolysis by NTPDase proteins
(inferredTo)	[Reaction:R-HSA-8851225] NTPDase4 hydrolyzes nucleoside diphosphates

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