Reactome | Synthesis of PIPs in the nucleus

Schema > Pathway > Entries

created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10827993
displayName	Synthesis of PIPs in the nucleus
eventOf	[Pathway:R-GGA-1483255] PI Metabolism - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[BlackBoxEvent:R-GGA-6810392] TMEM55B translocates to the nucleus - Gallus gallus [Reaction:R-GGA-6810410] PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus - Gallus gallus [Reaction:R-GGA-6811522] PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus - Gallus gallus
inferredFrom	[Pathway:R-HSA-8847453] Synthesis of PIPs in the nucleus - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Synthesis of PIPs in the nucleus
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49591] Gallus gallus
stId	R-GGA-8847453
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-GGA-1483255] PI Metabolism
(inferredTo)	[Pathway:R-HSA-8847453] Synthesis of PIPs in the nucleus

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