Reactome | Signal attenuation

Schema > Pathway > Entries

compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10825541
displayName	Signal attenuation
eventOf	[Pathway:R-GGA-74751] Insulin receptor signalling cascade - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-GGA-5686074] GRB2-1:p-4S-SOS1:p-Y427-SHC1 dissociates - Gallus gallus [Reaction:R-GGA-5686315] GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2 dissociates - Gallus gallus [Reaction:R-GGA-110011] Binding of Grb10 to the insulin receptor - Gallus gallus
inferredFrom	[Pathway:R-HSA-74749] Signal attenuation - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Signal attenuation
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49591] Gallus gallus
stId	R-GGA-74749
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-GGA-74751] Insulin receptor signalling cascade
(inferredTo)	[Pathway:R-HSA-74749] Signal attenuation