Reactome | ALDH9A1 tetramer dehydrogenates TEABL to form TEABT

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ALDH9A1 tetramer dehydrogenates TEABL to form TEABT Show undefined attributes

catalystActivity	[CatalystActivity:10734287] 4-trimethylammoniobutyraldehyde dehydrogenase activity of ALDH9A1 tetramer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10734289
displayName	ALDH9A1 tetramer dehydrogenates TEABL to form TEABT
eventOf	[Pathway:R-GGA-71262] Carnitine synthesis - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-GGA-71261] BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA - Gallus gallus
inferredFrom	[Reaction:R-HSA-71260] ALDH9A1 tetramer dehydrogenates TEABL to form TEABT - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-29360] NAD+ [cytosol] [SimpleEntity:R-ALL-31311] TEABL [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	ALDH9A1 tetramer dehydrogenates TEABL to form TEABT 4-(trimethylamino)butanal + H2O + NAD(+) => 4-(trimethylamino)butanoate + 2 H(+) + NADH gamma-butyrobetaine semialdehyde + NAD+ => gamma-butyrobetaine + NADH + H+
output	2 × [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-73473] NADH [cytosol] [SimpleEntity:R-ALL-31369] TEABT [cytosol]
precedingEvent	[Reaction:R-GGA-71249] SHMT1 tetramer cleaves HTMLYS to yield TEABL and Gly - Gallus gallus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-71260
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-71262] Carnitine synthesis
(precedingEvent)	[Reaction:R-GGA-71261] BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA
(inferredTo)	[Reaction:R-HSA-71260] ALDH9A1 tetramer dehydrogenates TEABL to form TEABT

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