Reactome | SLC22A4 transports BET from mitochondrial matrix to cytosol

Schema > Reaction > Entries

SLC22A4 transports BET from mitochondrial matrix to cytosol Show undefined attributes

catalystActivity	[CatalystActivity:10799708] amino-acid betaine transmembrane transporter activity of SLC22A4 [mitochondrial outer membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:5460] mitochondrial matrix
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10799710
displayName	SLC22A4 transports BET from mitochondrial matrix to cytosol
eventOf	[Pathway:R-GGA-6798163] Choline catabolism - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-GGA-1614654] BHMT tetramer transfers CH3 group from BET to HCYS to form DMGLY - Gallus gallus
inferredFrom	[Reaction:R-HSA-6797957] SLC22A4 transports BET from mitochondrial matrix to cytosol - Homo sapiens
input	[SimpleEntity:R-ALL-6798202] BET [mitochondrial matrix] [SimpleEntity:R-ALL-2889083] Na+ [mitochondrial matrix]
isInDisease	false
isInferred	true
maxDepth	1
name	SLC22A4 transports BET from mitochondrial matrix to cytosol glycine betaine(out) + Na(+)(out) = glycine betaine(in) + Na(+)(in) BET translocates from mitochondrial matrix to cytosol
output	[SimpleEntity:R-ALL-352015] BET [cytosol] [SimpleEntity:R-ALL-83910] Na+ [cytosol]
precedingEvent	[Reaction:R-GGA-6797955] ALDH7A1 oxidises BETALD to BET - Gallus gallus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-6797957
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-6798163] Choline catabolism
(precedingEvent)	[Reaction:R-GGA-1614654] BHMT tetramer transfers CH3 group from BET to HCYS to form DMGLY
(inferredTo)	[Reaction:R-HSA-6797957] SLC22A4 transports BET from mitochondrial matrix to cytosol

Cite Us!