Reactome | Membrane-bound myeloperoxidase (MPO) produces hypochlorous acid (HOCl)

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Membrane-bound myeloperoxidase (MPO) produces hypochlorous acid (HOCl) Show undefined attributes

catalystActivity	[CatalystActivity:10798936] peroxidase activity of MPO:ferriheme:bacterial cell surface [phagocytic vesicle lumen]
category	transition
compartment	[Compartment:21994] phagocytic vesicle [Compartment:1222282] phagocytic vesicle lumen
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10798938
displayName	Membrane-bound myeloperoxidase (MPO) produces hypochlorous acid (HOCl)
eventOf	[Pathway:R-GGA-8941413] Events associated with phagocytolytic activity of PMN cells - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-6789031] Membrane-bound myeloperoxidase (MPO) produces hypochlorous acid (HOCl) - Homo sapiens
input	[SimpleEntity:R-ALL-6788973] Cl- [phagocytic vesicle lumen] [SimpleEntity:R-ALL-1470067] H+ [phagocytic vesicle lumen] [SimpleEntity:R-ALL-1222719] H2O2 [phagocytic vesicle lumen]
isInDisease	false
isInferred	true
maxDepth	1
name	Membrane-bound myeloperoxidase (MPO) produces hypochlorous acid (HOCl)
output	[SimpleEntity:R-ALL-1222475] H2O [phagocytic vesicle lumen] [SimpleEntity:R-ALL-6789150] HOCl [phagocytic vesicle lumen]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-6789031
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-8941413] Events associated with phagocytolytic activity of PMN cells
(inferredTo)	[Reaction:R-HSA-6789031] Membrane-bound myeloperoxidase (MPO) produces hypochlorous acid (HOCl)

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