Reactome | D-loop formation mediated by PALB2, BRCA2 and RAD51

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D-loop formation mediated by PALB2, BRCA2 and RAD51 Show undefined attributes

category	binding
compartment	[Compartment:7660] nucleoplasm [Compartment:1598585] chromosome
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10796726
displayName	D-loop formation mediated by PALB2, BRCA2 and RAD51
eventOf	[Pathway:R-GGA-5693579] Homologous DNA Pairing and Strand Exchange - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-GGA-5685838] CX3 complex binds D-loop structures - Gallus gallus
inferredFrom	[Reaction:R-HSA-5693620] D-loop formation mediated by PALB2, BRCA2 and RAD51 - Homo sapiens
input	[Complex:R-GGA-5685343] 3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2:SEM1:BCDX2 complex [nucleoplasm] [EntityWithAccessionedSequence:R-GGA-419548] PALB2 [nucleoplasm] [EntityWithAccessionedSequence:R-GGA-5685301] RAD51AP1 [nucleoplasm] [OtherEntity:R-ALL-1638790] Sister Chromatid [chromosome]
isInDisease	false
isInferred	true
maxDepth	1
name	D-loop formation mediated by PALB2, BRCA2 and RAD51 Strand exchange/Branch migration mediated by PALB2, BRCA2 and RAD51
output	[Complex:R-GGA-5685658] D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm]
precedingEvent	[Reaction:R-GGA-5685341] BCDX2 complex stabilizes RAD51 filament - Gallus gallus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-5693620
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-5693579] Homologous DNA Pairing and Strand Exchange
(precedingEvent)	[Reaction:R-GGA-5685838] CX3 complex binds D-loop structures
(inferredTo)	[Reaction:R-HSA-5693620] D-loop formation mediated by PALB2, BRCA2 and RAD51

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