Reactome | USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN

Schema > Reaction > Entries

USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN Show undefined attributes

catalystActivity	[CatalystActivity:10795728] cysteine-type deubiquitinase activity of USP7:PolyUb-TP53,PolyUb-MDM2,PolyUb-MDM4,PolyUb-FOXO4,PolyUb-PTEN [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10795730
displayName	USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
eventOf	[Pathway:R-GGA-5689880] Ub-specific processing proteases - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-5689950] USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN - Homo sapiens
input	[SimpleEntity:R-ALL-113518] H2O [nucleoplasm] [Complex:R-GGA-6782666] USP7:PolyUb-TP53,PolyUb-MDM2,PolyUb-MDM4,PolyUb-FOXO4,PolyUb-PTEN [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
output	[DefinedSet:R-GGA-6782682] PolyUb [nucleoplasm] [Complex:R-GGA-6782656] USP7:TP53,MDM2,MDM4,FOXO4,PTEN [nucleoplasm]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-5689950
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-5689880] Ub-specific processing proteases
(inferredTo)	[Reaction:R-HSA-5689950] USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN

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