Reactome | ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm]

Schema > Complex > Entries

ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] Show undefined attributes

compartment	[Compartment:7660] nucleoplasm
componentOf	[Complex:R-GGA-5693547] p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] - Gallus gallus
consumedByEvent	[Reaction:R-GGA-5693580] Association of RAD52 with the RPA complex at resected DNA DSBs - Gallus gallus [Reaction:R-GGA-5684882] CHEK1 is recruited to resected DNA DSBs - Gallus gallus
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10794734
displayName	ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm]
hasComponent	[Complex:R-GGA-5685178] ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex [nucleoplasm] [DefinedSet:R-GGA-5685980] EXO1,DNA2:BLM,WRN [nucleoplasm] [GenomeEncodedEntity:R-GGA-5684880] Ghost homologue of RHNO1 [nucleoplasm] [EntityWithAccessionedSequence:R-GGA-5687710] phospho-p-S990,Ac-K1249-BRIP1 [nucleoplasm] [Complex:R-GGA-176353] RAD17:RFC [nucleoplasm] [Complex:R-GGA-176312] RAD9:HUS1:RAD1 [nucleoplasm] [EntityWithAccessionedSequence:R-GGA-5684878] TOPBP1 [nucleoplasm]
inDisease	false
inferredFrom	[Complex:R-HSA-5685162] ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] - Homo sapiens
maxDepth	7
name	ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1
producedByEvent	[Reaction:R-GGA-5684887] Activation of CHEK1 at resected DNA DSBs - Gallus gallus [Reaction:R-GGA-5685156] ATR phosphorylates RPA2 - Gallus gallus
schemaClass	Complex
species	[Species:49591] Gallus gallus
stId	R-GGA-5685162
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

Referrals

(output)	[Reaction:R-GGA-5684887] Activation of CHEK1 at resected DNA DSBs [Reaction:R-GGA-5685156] ATR phosphorylates RPA2
(input)	[Reaction:R-GGA-5684882] CHEK1 is recruited to resected DNA DSBs [Reaction:R-GGA-5693580] Association of RAD52 with the RPA complex at resected DNA DSBs
(hasComponent)	[Complex:R-GGA-5693547] p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm]
(inferredTo)	[Complex:R-HSA-5685162] ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm]

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