Reactome | LGI-ADAM interactions

Schema > Pathway > Entries

compartment	[Compartment:984] extracellular region
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10827861
displayName	LGI-ADAM interactions
eventOf	[TopLevelPathway:R-GGA-1266738] Developmental Biology - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-GGA-5682826] LGI1 binds ADAM11 - Gallus gallus [Reaction:R-GGA-5682769] LGI2 binds ADAM22,23 - Gallus gallus
inferredFrom	[Pathway:R-HSA-5682910] LGI-ADAM interactions - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	LGI-ADAM interactions
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49591] Gallus gallus
stId	R-GGA-5682910
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[TopLevelPathway:R-GGA-1266738] Developmental Biology
(inferredTo)	[Pathway:R-HSA-5682910] LGI-ADAM interactions

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