Reactome | TNFSF:TNFRSF heterotrimer:K63polyUb-cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane]

Schema > Complex > Entries

catalystActivities	[CatalystActivity:10793231] ubiquitin-protein transferase activity of TNFSF:TNFRSF heterotrimer:K63polyUb-cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane]
compartment	[Compartment:876] plasma membrane
consumedByEvent	[BlackBoxEvent:R-GGA-5668454] K63polyUb-cIAP1,2 ubiquitinates TRAF3 - Gallus gallus
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10793220
displayName	TNFSF:TNFRSF heterotrimer:K63polyUb-cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane]
hasComponent	[DefinedSet:R-GGA-5676550] TNFA:TNFR2,BAFF:BAFFR,TWEAK:Fn14,Lymphotoxin:LTBR,RANKL:RANK,CD40L:CD40 [plasma membrane] [Complex:R-GGA-5668475] TRAF1:TRAF2:K63polyUb-cIAP1,2 [cytosol] [Complex:R-GGA-5668511] TRAF3:NIK [cytosol]
inDisease	false
inferredFrom	[Complex:R-HSA-5668433] TNFSF:TNFRSF heterotrimer:K63polyUb-cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] - Homo sapiens
maxDepth	6
name	TNFSF:TNFRSF heterotrimer:K63polyUb-cIAP1,2:TRAF2:TRAF3:NIK
negativelyRegulates	[NegativeRegulation:10793244] Negative regulation by 'TNFSF:TNFRSF heterotrimer:K63polyUb-cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane]'
producedByEvent	[BlackBoxEvent:R-GGA-5668414] TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK - Gallus gallus
schemaClass	Complex
species	[Species:49591] Gallus gallus
stId	R-GGA-5668433
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

(regulator)	[NegativeRegulation:10793244] Negative regulation by 'TNFSF:TNFRSF heterotrimer:K63polyUb-cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane]'
(input)	[BlackBoxEvent:R-GGA-5668454] K63polyUb-cIAP1,2 ubiquitinates TRAF3
(physicalEntity)	[CatalystActivity:10793231] ubiquitin-protein transferase activity of TNFSF:TNFRSF heterotrimer:K63polyUb-cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane]
(output)	[BlackBoxEvent:R-GGA-5668414] TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK
(inferredTo)	[Complex:R-HSA-5668433] TNFSF:TNFRSF heterotrimer:K63polyUb-cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane]

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