Reactome | SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments

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SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments Show undefined attributes

catalystActivity	[CatalystActivity:10793046] GTPase activity of SRGAP2:RAC1:GTP:FMNL1:Profilin:G-actin [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10793048
displayName	SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments
eventOf	[Pathway:R-GGA-5663220] RHO GTPases Activate Formins - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-5665809] SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [Complex:R-GGA-5665803] SRGAP2:RAC1:GTP:FMNL1:Profilin:G-actin [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments
output	[Complex:R-GGA-5665949] FMNL1 [cytosol] [SimpleEntity:R-ALL-29372] Pi [cytosol] 2 × [Complex:R-GGA-203080] Profilin:G-actin [cytosol] [Complex:R-GGA-445010] RAC1:GDP [cytosol] [EntityWithAccessionedSequence:R-GGA-195131] SRGAP2 [cytosol]
precedingEvent	[Reaction:R-GGA-5665802] SRGAP2 binds RAC1:GTP:FMNL1:profilin:G-actin - Gallus gallus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-5665809
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-5663220] RHO GTPases Activate Formins
(inferredTo)	[Reaction:R-HSA-5665809] SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments

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