Reactome | Tyrosinase oxidises tyrosine to dopaquinone

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Tyrosinase oxidises tyrosine to dopaquinone Show undefined attributes

catalystActivity	[CatalystActivity:10792963] catechol oxidase activity of TYR:2xCu2+ [melanosome membrane]
category	transition
compartment	[Compartment:5668575] melanosome membrane [Compartment:5668572] melanosome lumen
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10792973
displayName	Tyrosinase oxidises tyrosine to dopaquinone
eventOf	[Pathway:R-GGA-5662702] Melanin biosynthesis - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-5662662] Tyrosinase oxidises tyrosine to dopaquinone - Homo sapiens
input	[SimpleEntity:R-ALL-5668567] L-Tyr [melanosome lumen] [SimpleEntity:R-ALL-5668566] O2 [melanosome lumen]
isInDisease	false
isInferred	true
maxDepth	1
name	Tyrosinase oxidises tyrosine to dopaquinone L-tyrosine + O2 => L-dopaquinone + H2O
output	[SimpleEntity:R-ALL-5668574] H2O [melanosome lumen] [SimpleEntity:R-ALL-5662695] L-Dopaquinone [melanosome lumen]
regulatedBy	[PositiveRegulation:10792974] Positive regulation by 'OCA2 [melanosome membrane]' [PositiveRegulation:10792975] Positive regulation by 'SLC45A2 [melanosome membrane]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-5662662
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-5662702] Melanin biosynthesis
(inferredTo)	[Reaction:R-HSA-5662662] Tyrosinase oxidises tyrosine to dopaquinone

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