Reactome | ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA

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ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA Show undefined attributes

catalystActivity	[CatalystActivity:10762140] fatty acid elongase activity of ELOVL3,6,7 [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10762142
displayName	ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA
eventOf	[Pathway:R-GGA-75876] Synthesis of very long-chain fatty acyl-CoAs - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-GGA-548818] HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA - Gallus gallus
inferredFrom	[Reaction:R-HSA-548814] ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA - Homo sapiens
input	[SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29508] Mal-CoA [cytosol] [SimpleEntity:R-ALL-200993] PALM-CoA [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA H(+) + hexadecanoyl-CoA + malonyl-CoA => 3-oxooctadecanoyl-CoA + CO2 + CoA palmitoyl-CoA + malonyl-CoA => 3-oxooctadecanoyl-CoA (3-oxostearoyl-CoA) + CO2 + CoASH
output	[SimpleEntity:R-ALL-548812] 3OOD-CoA [cytosol] [SimpleEntity:R-ALL-113528] CO2 [cytosol] [SimpleEntity:R-ALL-76194] CoA-SH [cytosol]
precedingEvent	[Reaction:R-GGA-201035] ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA - Gallus gallus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-548814
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-75876] Synthesis of very long-chain fatty acyl-CoAs
(precedingEvent)	[Reaction:R-GGA-548818] HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA
(inferredTo)	[Reaction:R-HSA-548814] ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA

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