Reactome | Aflatoxin activation and detoxification

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Aflatoxin activation and detoxification Show undefined attributes

created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10825759
displayName	Aflatoxin activation and detoxification
eventOf	[Pathway:R-GGA-211859] Biological oxidations - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:19771] aflatoxin metabolic process
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-GGA-5423664] CYP3A4,5 hydroxylates AFB1 to AFQ1 - Gallus gallus [Reaction:R-GGA-156526] CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO - Gallus gallus [Reaction:R-GGA-5423672] CYP1A2, 3A4 oxidise AFB1 to AFNBO - Gallus gallus [Reaction:R-GGA-5423653] MGST trimers transfer GS from GSH to AFXBO and AFNBO - Gallus gallus [Reaction:R-GGA-5433072] GGTs hydrolyse glutamate from AFXBO-SG, AFNBO-SG - Gallus gallus [Reaction:R-GGA-5433067] DPEPs hydrolyse glycine from AFXBO-CG, AFNBO-CG - Gallus gallus [Reaction:R-GGA-5433074] ACY1:Zn2+ dimer hydrolyses mercapturic acids - Gallus gallus [Reaction:R-GGA-5423637] AKR dimers reduce AFBDHO to AFBDOH - Gallus gallus
inferredFrom	[Pathway:R-HSA-5423646] Aflatoxin activation and detoxification - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Aflatoxin activation and detoxification
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49591] Gallus gallus
stId	R-GGA-5423646
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-211859] Biological oxidations
(inferredTo)	[Pathway:R-HSA-5423646] Aflatoxin activation and detoxification

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