Reactome | PAK2 binds NCK

Schema > Reaction > Entries

category	binding
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10788445
displayName	PAK2 binds NCK
eventOf	[Pathway:R-GGA-4420097] VEGFA-VEGFR2 Pathway - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-GGA-5218832] CDC42:GTP binds PAK2 - Gallus gallus
inferredFrom	[Reaction:R-HSA-5218847] PAK2 binds NCK - Homo sapiens
input	[Complex:R-GGA-2685645] PAK2 dimer [cytosol] [Complex:R-GGA-5218780] VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	PAK2 binds NCK
output	[Complex:R-GGA-5218766] VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN:PAK2 [plasma membrane]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-5218847
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-GGA-4420097] VEGFA-VEGFR2 Pathway
(precedingEvent)	[Reaction:R-GGA-5218832] CDC42:GTP binds PAK2
(inferredTo)	[Reaction:R-HSA-5218847] PAK2 binds NCK