Reactome | Src kinases phosphorylate VAV

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Src kinases phosphorylate VAV Show undefined attributes

catalystActivity	[CatalystActivity:10788212] protein tyrosine kinase activity of VEGFA:p-6Y-VEGFR2:p-SHB:p-Y397-PTK2:SRC-1 [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10788371
displayName	Src kinases phosphorylate VAV
eventOf	[Pathway:R-GGA-4420097] VEGFA-VEGFR2 Pathway - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-GGA-8951586] p-VAV family:PIP3 binds RAC1:GDP - Gallus gallus
inferredFrom	[Reaction:R-HSA-5218820] Src kinases phosphorylate VAV - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-GGA-5340329] PIP3:VAV1,2,3 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Src kinases phosphorylate VAV
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-GGA-5218789] p-VAV family:PIP3 [plasma membrane]
precedingEvent	[Reaction:R-GGA-5218645] SRC-1 binds p-Y397-PTK2 - Gallus gallus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-5218820
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-4420097] VEGFA-VEGFR2 Pathway
(precedingEvent)	[Reaction:R-GGA-8951586] p-VAV family:PIP3 binds RAC1:GDP
(inferredTo)	[Reaction:R-HSA-5218820] Src kinases phosphorylate VAV

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