Reactome | TLR7 binds to recognized ligands

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TLR7 binds to recognized ligands Show undefined attributes

authored	[InstanceEdit:451550] Shamovsky, V, 2010-01-05
category	binding
compartment	[Compartment:74700] endosome membrane [Compartment:171907] endosome lumen
created	[InstanceEdit:451501] Shamovsky, V, 2010-01-05
dbId	451481
displayName	TLR7 binds to recognized ligands
edited	[InstanceEdit:1221606] Shamovsky, V, 2011-02-24
eventOf	[Pathway:R-GGA-451498] TLR7 cascade - Gallus gallus
followingEvent	[Reaction:R-GGA-451439] Activated TLR7 or 21 recruits MyD88 - Gallus gallus [Reaction:R-GGA-433961] Activated TLR homo- or heterodimer recruits adaptors TIRAP(or MAL) and MyD88 - Gallus gallus
input	2 × [EntityWithAccessionedSequence:R-GGA-451496] chicken TLR7 [endosome membrane] [DefinedSet:R-ALL-188130] Ligands recognized by chicken TLR7 [endosome lumen]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:451492] Identification and characterization of a functional, alternatively spliced Toll-like receptor 7 (TLR7) and genomic disruption of TLR8 in chickens
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	TLR7 binds to recognized ligands
output	[Complex:R-GGA-451537] chicken TLR7 homodimer bound to recognized ligands [endosome membrane]
releaseDate	2011-03-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1112618] D'Eustachio, P, 2010-12-06
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-451481
summation	[Summation:993996] Strong up-regulation of IL-1beta but not type 1 interferons ...
updateTrackers	[UpdateTracker:9777030] Update Tracker - [Reaction:451481] TLR7 binds to recognized ligands - v73:[add_removeInput]

Referrals

(updatedInstance)	[UpdateTracker:9777030] Update Tracker - [Reaction:451481] TLR7 binds to recognized ligands - v73:[add_removeInput]
(hasEvent)	[Pathway:R-GGA-451498] TLR7 cascade
(precedingEvent)	[Reaction:R-GGA-451439] Activated TLR7 or 21 recruits MyD88 [Reaction:R-GGA-433961] Activated TLR homo- or heterodimer recruits adaptors TIRAP(or MAL) and MyD88

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