Reactome | Auto ubiquitination of the TRAF6 within the complex viral dsRNA:TLR3:TICAM1:TRAF6

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Auto ubiquitination of the TRAF6 within the complex viral dsRNA:TLR3:TICAM1:TRAF6 Show undefined attributes

authored	[InstanceEdit:434153] Shamovsky, V, 2009-08-26
catalystActivity	[CatalystActivity:434017] ubiquitin-protein transferase activity of viral ds RNA : TLR3 : TICAM1 : TRAF6 [endosome membrane]
category	omitted
compartment	[Compartment:74700] endosome membrane [Compartment:70101] cytosol
created	[InstanceEdit:434122] Shamovsky, V, 2009-08-26
dbId	433981
displayName	Auto ubiquitination of the TRAF6 within the complex viral dsRNA:TLR3:TICAM1:TRAF6
edited	[InstanceEdit:668815] Shamovsky, V, 2010-05-04
eventOf	[Pathway:R-GGA-433871] TRAF6 mediated induction of proinflammatory cytokines - Gallus gallus
followingEvent	[BlackBoxEvent:R-GGA-433936] Activated chicken TRAF6 synthesizes free K63bound poly_Ub chains within the complex dsRNA :TLR3 :TICAM1 - Gallus gallus
inferredFrom	[BlackBoxEvent:R-HSA-450259] Auto ubiqitination of TRAF6 bound to viral dsRNS:TLR3:TICAM1 complex - Homo sapiens
input	[Complex:R-GGA-446245] Ubiquitin:UBE2N : UBE2V complex [cytosol] [Complex:R-GGA-433968] viral ds RNA : TLR3 : TICAM1 : TRAF6 [endosome membrane]
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:202511] Site-specific Lys-63-linked tumor necrosis factor receptor-associated factor 6 auto-ubiquitination is a critical determinant of I kappa B kinase activation
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Auto ubiquitination of the TRAF6 within the complex viral dsRNA:TLR3:TICAM1:TRAF6
output	[Complex:R-GGA-433960] UBE2N : UBE2V complex [cytosol] [Complex:R-GGA-434102] viral ds RNA : TLR3 : TICAM1 : pUb-TRAF6 [endosome membrane]
precedingEvent	[Reaction:R-GGA-433808] viral dsRNA: TLR3: TICAM1 recruits TRAF6 - Gallus gallus
relatedSpecies	[Species:9014381] Infectious bronchitis virus
releaseDate	2010-12-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:789693] D'Eustachio, P, 2010-05-23
schemaClass	BlackBoxEvent
species	[Species:49591] Gallus gallus
stId	R-GGA-433981
summation	[Summation:202446] TRAF6 possesses ubiquitin ligase activity and undergoes K-63...
updateTrackers	[UpdateTracker:9789956] Update Tracker - [BlackBoxEvent:433981] Auto ubiquitination of the TRAF6 within the complex viral dsRNA:TLR3:TICAM1:TRAF6 - v36:[modifyText] [UpdateTracker:9788221] Update Tracker - [BlackBoxEvent:433981] Auto ubiquitination of the TRAF6 within the complex viral dsRNA:TLR3:TICAM1:TRAF6 - v43:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9789956] Update Tracker - [BlackBoxEvent:433981] Auto ubiquitination of the TRAF6 within the complex viral dsRNA:TLR3:TICAM1:TRAF6 - v36:[modifyText] [UpdateTracker:9788221] Update Tracker - [BlackBoxEvent:433981] Auto ubiquitination of the TRAF6 within the complex viral dsRNA:TLR3:TICAM1:TRAF6 - v43:[modifyText]
(hasEvent)	[Pathway:R-GGA-433871] TRAF6 mediated induction of proinflammatory cytokines
(precedingEvent)	[BlackBoxEvent:R-GGA-433936] Activated chicken TRAF6 synthesizes free K63bound poly_Ub chains within the complex dsRNA :TLR3 :TICAM1
(inferredTo)	[BlackBoxEvent:R-HSA-450259] Auto ubiqitination of TRAF6 bound to viral dsRNS:TLR3:TICAM1 complex

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