Reactome | SLC5A3 (SMIT1) transports myo-inositol (Ins) with Na+ from extracellular region to cytosol

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SLC5A3 (SMIT1) transports myo-inositol (Ins) with Na+ from extracellular region to cytosol Show undefined attributes

catalystActivity	[CatalystActivity:10758674] myo-inositol:sodium symporter activity of SLC5A3 [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10758676
displayName	SLC5A3 (SMIT1) transports myo-inositol (Ins) with Na+ from extracellular region to cytosol
eventOf	[Pathway:R-GGA-429593] Inositol transporters - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-429663] SLC5A3 (SMIT1) transports myo-inositol (Ins) with Na+ from extracellular region to cytosol - Homo sapiens
input	[SimpleEntity:R-ALL-429130] Ins [extracellular region] 2 × [SimpleEntity:R-ALL-74113] Na+ [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	SLC5A3 (SMIT1) transports myo-inositol (Ins) with Na+ from extracellular region to cytosol Co-transport (influx) of myo-inositol and two Na+ ions by SMIT
output	[SimpleEntity:R-ALL-426910] Ins [cytosol] 2 × [SimpleEntity:R-ALL-83910] Na+ [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-429663
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-429593] Inositol transporters
(inferredTo)	[Reaction:R-HSA-429663] SLC5A3 (SMIT1) transports myo-inositol (Ins) with Na+ from extracellular region to cytosol

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