Reactome | PXLP-SGPL1 cleaves sphingoid-1-phosphates

Schema > Reaction > Entries

PXLP-SGPL1 cleaves sphingoid-1-phosphates Show undefined attributes

catalystActivity	[CatalystActivity:10758486] sphinganine-1-phosphate aldolase activity of PXLP-SGPL1 [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10758488
displayName	PXLP-SGPL1 cleaves sphingoid-1-phosphates
eventOf	[Pathway:R-GGA-9845614] Sphingolipid catabolism - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-GGA-5696080] ALDH3B1 oxidises HXAL to PALM - Gallus gallus [Reaction:R-GGA-5692261] ALDH3A2-1 oxidises HD2NAL to PALM - Gallus gallus [Reaction:R-GGA-6808464] ALDH3B2 oxidises HXAL to PALM - Gallus gallus
inferredFrom	[Reaction:R-HSA-428681] PXLP-SGPL1 cleaves sphingoid-1-phosphates - Homo sapiens
input	[DefinedSet:R-ALL-9844328] S1P,SPAP [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	PXLP-SGPL1 cleaves sphingoid-1-phosphates sphinganine 1-phosphate => phosphoethanolamine + hexadecanal
output	[DefinedSet:R-ALL-9844327] HXAL,HD2NAL [cytosol] [SimpleEntity:R-ALL-428686] PETA [cytosol]
precedingEvent	[Reaction:R-GGA-428273] SPHK1 phosphorylates sphingoid - Gallus gallus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-428681
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-9845614] Sphingolipid catabolism
(precedingEvent)	[Reaction:R-GGA-5696080] ALDH3B1 oxidises HXAL to PALM [Reaction:R-GGA-5692261] ALDH3A2-1 oxidises HD2NAL to PALM [Reaction:R-GGA-6808464] ALDH3B2 oxidises HXAL to PALM
(inferredTo)	[Reaction:R-HSA-428681] PXLP-SGPL1 cleaves sphingoid-1-phosphates

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