Reactome | DAG is metabolized by DAGL to 2-AG

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DAG is metabolized by DAGL to 2-AG Show undefined attributes

catalystActivity	[CatalystActivity:10758020] monoacylglycerol lipase activity of Diacylglycerol lipase [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10758022
displayName	DAG is metabolized by DAGL to 2-AG
eventOf	[Pathway:R-GGA-426048] Arachidonate production from DAG - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-GGA-426043] 2-AG hydrolysis to arachidonate by MAGL - Gallus gallus
inferredFrom	[Reaction:R-HSA-426032] DAG is metabolized by DAGL to 2-AG - Homo sapiens
input	[SimpleEntity:R-ALL-114519] DAG [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	DAG is metabolized by DAGL to 2-AG
output	[SimpleEntity:R-ALL-426030] 2AG [plasma membrane] [SimpleEntity:R-ALL-426026] Fatty Acid [plasma membrane]
precedingEvent	[Reaction:R-GGA-114688] PLC-beta hydrolyses PIP2 to DAG and IP3 - Gallus gallus [Reaction:R-GGA-398193] PLC beta-mediated PIP2 hydrolysis - Gallus gallus [Reaction:R-GGA-114689] PLC gamma 2-mediated PIP2 hydrolysis - Gallus gallus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-426032
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-426048] Arachidonate production from DAG
(precedingEvent)	[Reaction:R-GGA-426043] 2-AG hydrolysis to arachidonate by MAGL
(inferredTo)	[Reaction:R-HSA-426032] DAG is metabolized by DAGL to 2-AG

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