Reactome | P2RY12 binds ADP

Schema > Reaction > Entries

P2RY12 binds ADP Show undefined attributes

category	binding
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10756932
displayName	P2RY12 binds ADP
eventOf	[Pathway:R-GGA-392170] ADP signalling through P2Y purinoceptor 12 - Gallus gallus [Pathway:R-GGA-417957] P2Y receptors - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-GGA-392187] Activated P2Y purinoceptor 12 binds G-protein Gi - Gallus gallus [Reaction:R-GGA-749456] Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi - Gallus gallus
inferredFrom	[Reaction:R-HSA-417829] P2RY12 binds ADP - Homo sapiens
input	[SimpleEntity:R-ALL-114564] ADP [extracellular region] [EntityWithAccessionedSequence:R-GGA-391959] P2RY12 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	P2RY12 binds ADP
output	[Complex:R-GGA-417834] P2RY12:ADP [plasma membrane]
regulatedBy	[NegativeRegulation:10756933] Negative regulation by 'P2RY12:P2RY12 antagonists [plasma membrane]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-417829
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-392170] ADP signalling through P2Y purinoceptor 12 [Pathway:R-GGA-417957] P2Y receptors
(precedingEvent)	[Reaction:R-GGA-392187] Activated P2Y purinoceptor 12 binds G-protein Gi [Reaction:R-GGA-749456] Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi
(inferredTo)	[Reaction:R-HSA-417829] P2RY12 binds ADP