Reactome | Gi activation by P2Y purinoceptor 12

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Gi activation by P2Y purinoceptor 12 Show undefined attributes

catalystActivity	[CatalystActivity:10756314] guanyl-nucleotide exchange factor activity of ADP:P2RY12:G-protein Gi (inactive) [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10756316
displayName	Gi activation by P2Y purinoceptor 12
eventOf	[Pathway:R-GGA-392170] ADP signalling through P2Y purinoceptor 12 - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-GGA-392202] Dissociation of the P2Y purinoceptor 12:Gi complex - Gallus gallus
inferredFrom	[Reaction:R-HSA-392195] Gi activation by P2Y purinoceptor 12 - Homo sapiens
input	[Complex:R-GGA-392184] ADP:P2RY12:G-protein Gi (inactive) [plasma membrane] [SimpleEntity:R-ALL-29438] GTP [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Gi activation by P2Y purinoceptor 12
output	[Complex:R-GGA-392194] ADP:P2RY12:G-protein Gi (active) [plasma membrane] [SimpleEntity:R-ALL-29420] GDP [cytosol]
precedingEvent	[Reaction:R-GGA-392187] Activated P2Y purinoceptor 12 binds G-protein Gi - Gallus gallus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-392195
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-392170] ADP signalling through P2Y purinoceptor 12
(precedingEvent)	[Reaction:R-GGA-392202] Dissociation of the P2Y purinoceptor 12:Gi complex
(inferredTo)	[Reaction:R-HSA-392195] Gi activation by P2Y purinoceptor 12

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