Reactome | CTLA-4 binds B7-1/B7-2

Schema > Reaction > Entries

category	binding
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10755483
displayName	CTLA-4 binds B7-1/B7-2
eventOf	[Pathway:R-GGA-389513] Co-inhibition by CTLA4 - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-388809] CTLA-4 binds B7-1/B7-2 - Homo sapiens
input	[DefinedSet:R-GGA-388762] B7-1 homodimer/ B7-2 [plasma membrane] [Complex:R-GGA-389533] CTLA4 dimer:PP2A [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	CTLA-4 binds B7-1/B7-2
output	[Complex:R-GGA-388784] PP2A:CTLA4:B7-1/B7-2 [plasma membrane]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-388809
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-GGA-389513] Co-inhibition by CTLA4
(inferredTo)	[Reaction:R-HSA-388809] CTLA-4 binds B7-1/B7-2

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