Reactome | COMT transfers Met to DA to form 3MT

Schema > Reaction > Entries

COMT transfers Met to DA to form 3MT Show undefined attributes

catalystActivity	[CatalystActivity:10754085] methyltransferase activity of COMT [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10754089
displayName	COMT transfers Met to DA to form 3MT
eventOf	[Pathway:R-GGA-379397] Enzymatic degradation of dopamine by COMT - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-379387] COMT transfers Met to DA to form 3MT - Homo sapiens
input	[SimpleEntity:R-ALL-71284] AdoMet [cytosol] [SimpleEntity:R-ALL-159362] DA [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	COMT transfers Met to DA to form 3MT methylation of Dopamine to form 3-Methoxytyramine
output	[SimpleEntity:R-ALL-8954997] 3MT [cytosol] [SimpleEntity:R-ALL-71285] AdoHcy [cytosol]
regulatedBy	[NegativeRegulation:10754090] Negative regulation by 'COMT:COMT inhibitors [plasma membrane]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-379387
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-379397] Enzymatic degradation of dopamine by COMT
(inferredTo)	[Reaction:R-HSA-379387] COMT transfers Met to DA to form 3MT

Cite Us!