Reactome | SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol

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SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol Show undefined attributes

catalystActivity	[CatalystActivity:10752987] amino acid transmembrane transporter activity of SLC6A14 [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10752989
displayName	SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol
eventOf	[Pathway:R-GGA-442660] SLC-mediated transport of neurotransmitters - Gallus gallus [Pathway:R-GGA-352230] Amino acid transport across the plasma membrane - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-GGA-428625] Vesicular inhibitory amino acid transport - Gallus gallus
inferredFrom	[Reaction:R-HSA-375487] SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol - Homo sapiens
input	[SimpleEntity:R-ALL-188972] Cl- [extracellular region] 2 × [SimpleEntity:R-ALL-74113] Na+ [extracellular region] [DefinedSet:R-ALL-375468] SLC6A14 ligands [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol SLC6A14-mediated uptake of basic and neutral amino acids and of beta-alanine
output	[SimpleEntity:R-ALL-352022] Cl- [cytosol] 2 × [SimpleEntity:R-ALL-83910] Na+ [cytosol] [DefinedSet:R-ALL-375459] SLC6A14 ligands [cytosol]
precedingEvent	[Reaction:R-GGA-352364] SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine - Gallus gallus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-375487
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-352230] Amino acid transport across the plasma membrane [Pathway:R-GGA-442660] SLC-mediated transport of neurotransmitters
(precedingEvent)	[Reaction:R-GGA-428625] Vesicular inhibitory amino acid transport
(inferredTo)	[Reaction:R-HSA-375487] SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol

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