Reactome | Caspase-3 [cytosol]

Schema > Complex > Entries

catalystActivities	[CatalystActivity:10748292] cysteine-type endopeptidase activity of Caspase-3 [cytosol]
compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-GGA-114304] XIAP:Caspase-3 [cytosol] - Gallus gallus
consumedByEvent	[Reaction:R-GGA-211219] Translocation of caspase-3 to the nucleus - Gallus gallus [Reaction:R-GGA-9627104] XIAP binds CASP3 - Gallus gallus
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10739080
displayName	Caspase-3 [cytosol]
hasComponent	2 × [Complex:R-GGA-350888] CASP3(29-175):CASP3(176-277) [cytosol]
inDisease	false
inferredFrom	[Complex:R-HSA-350870] Caspase-3 [cytosol] - Homo sapiens
maxDepth	3
memberOf	[DefinedSet:R-GGA-202877] Caspase-3, Caspase-7 [cytosol] - Gallus gallus [DefinedSet:R-GGA-205013] Active Caspases 2, 3 [cytosol] - Gallus gallus
name	Caspase-3
negativelyRegulates	[NegativeRegulation:10816993] Negative regulation by 'Caspase-3 [cytosol]'
producedByEvent	[Reaction:R-GGA-114252] Cleavage of Procaspase-3 by the apoptosome - Gallus gallus
schemaClass	Complex
species	[Species:49591] Gallus gallus
stId	R-GGA-350870
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

(hasMember)	[DefinedSet:R-GGA-205013] Active Caspases 2, 3 [cytosol] [DefinedSet:R-GGA-202877] Caspase-3, Caspase-7 [cytosol]
(regulator)	[NegativeRegulation:10816993] Negative regulation by 'Caspase-3 [cytosol]'
(input)	[Reaction:R-GGA-9627104] XIAP binds CASP3 [Reaction:R-GGA-211219] Translocation of caspase-3 to the nucleus
(physicalEntity)	[CatalystActivity:10748292] cysteine-type endopeptidase activity of Caspase-3 [cytosol]
(output)	[Reaction:R-GGA-114252] Cleavage of Procaspase-3 by the apoptosome
(hasComponent)	[Complex:R-GGA-114304] XIAP:Caspase-3 [cytosol]
(inferredTo)	[Complex:R-HSA-350870] Caspase-3 [cytosol]