Reactome | DAXX binds Ub-MDM2 and USP7

Schema > Reaction > Entries

DAXX binds Ub-MDM2 and USP7 Show undefined attributes

category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10784142
displayName	DAXX binds Ub-MDM2 and USP7
eventOf	[Pathway:R-GGA-6804757] Regulation of TP53 Degradation - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-GGA-3215295] USP7 deubiquitinates MDM2 - Gallus gallus
inferredFrom	[Reaction:R-HSA-3222072] DAXX binds Ub-MDM2 and USP7 - Homo sapiens
input	[EntityWithAccessionedSequence:R-GGA-3222068] DAXX [nucleoplasm] [CandidateSet:R-GGA-6805029] PolyUb,p-S166,S188-MDM2:(PolyUb,p-S166,S188-MDM2, PolyUb,p-S342,S367,S403-MDM4) [nucleoplasm] [EntityWithAccessionedSequence:R-GGA-3215278] USP7 [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	DAXX binds Ub-MDM2 and USP7
output	[Complex:R-GGA-3222079] DAXX:(PolyUb,p-S166,S188-MDM2):USP7 [nucleoplasm]
precedingEvent	[Reaction:R-GGA-6804942] MDM2 homodimers auto-ubiquitinate - Gallus gallus [Reaction:R-GGA-6804724] MDM2 ubiquitinates phosphorylated MDM4 - Gallus gallus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-3222072
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-6804757] Regulation of TP53 Degradation
(precedingEvent)	[Reaction:R-GGA-3215295] USP7 deubiquitinates MDM2
(inferredTo)	[Reaction:R-HSA-3222072] DAXX binds Ub-MDM2 and USP7