Reactome | ASIC trimers:H+ transport extracellular Na+ to cytosol

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ASIC trimers:H+ transport extracellular Na+ to cytosol Show undefined attributes

catalystActivity	[CatalystActivity:10782612] pH-gated monoatomic ion channel activity of ASIC trimers:H+ [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10782618
displayName	ASIC trimers:H+ transport extracellular Na+ to cytosol
eventOf	[Pathway:R-GGA-2672351] Stimuli-sensing channels - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-2671885] ASIC trimers:H+ transport extracellular Na+ to cytosol - Homo sapiens
input	[SimpleEntity:R-ALL-74113] Na+ [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	ASIC trimers:H+ transport extracellular Na+ to cytosol
output	[SimpleEntity:R-ALL-83910] Na+ [cytosol]
precedingEvent	[Reaction:R-GGA-9650165] ASIC trimers bind H+ - Gallus gallus
regulatedBy	[NegativeRegulation:10782619] Negative regulation by 'ASIC4 [plasma membrane]' [NegativeRegulation:R-HSA-2672386] Negative regulation by 'NSAID [extracellular region]' [NegativeRegulation:R-HSA-2672371] Negative regulation by 'amiloride [extracellular region]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-2671885
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-2672351] Stimuli-sensing channels
(inferredTo)	[Reaction:R-HSA-2671885] ASIC trimers:H+ transport extracellular Na+ to cytosol

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