Reactome | TRIF-mediated programmed cell death

Schema > Pathway > Entries

compartment	[Compartment:74700] endosome membrane [Compartment:70101] cytosol
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10827509
displayName	TRIF-mediated programmed cell death
eventOf	[Pathway:R-GGA-937061] TRIF (TICAM1)-mediated TLR4 signaling - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-GGA-2562541] TLR4-induced ripoptosome assembly - Gallus gallus [Reaction:R-GGA-2562564] Caspase-8 processing within TLR4 complex - Gallus gallus
inferredFrom	[Pathway:R-HSA-2562578] TRIF-mediated programmed cell death - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	TRIF-mediated programmed cell death
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49591] Gallus gallus
stId	R-GGA-2562578
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-GGA-937061] TRIF (TICAM1)-mediated TLR4 signaling
(inferredTo)	[Pathway:R-HSA-2562578] TRIF-mediated programmed cell death

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