Reactome | activated TLR4:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane]

Schema > Complex > Entries

catalystActivities	[CatalystActivity:10782523] cysteine-type endopeptidase activity of activated TLR4:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane]
compartment	[Compartment:74700] endosome membrane
consumedByEvent	[Reaction:R-GGA-2562564] Caspase-8 processing within TLR4 complex - Gallus gallus
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10782517
displayName	activated TLR4:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane]
hasComponent	2 × [EntityWithAccessionedSequence:R-GGA-57031] CASP8 [cytosol] 2 × [EntityWithAccessionedSequence:R-GGA-54639] FADD [cytosol] 2 × [EntityWithAccessionedSequence:R-GGA-168651] RIPK1 [cytosol] [Complex:R-GGA-166172] TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane]
inDisease	false
inferredFrom	[Complex:R-HSA-2562542] activated TLR4:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane] - Homo sapiens
maxDepth	6
name	activated TLR4:TRIF:RIP1:FADD:pro-caspase-8
producedByEvent	[Reaction:R-GGA-2562541] TLR4-induced ripoptosome assembly - Gallus gallus
schemaClass	Complex
species	[Species:49591] Gallus gallus
stId	R-GGA-2562542
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

(input)	[Reaction:R-GGA-2562564] Caspase-8 processing within TLR4 complex
(physicalEntity)	[CatalystActivity:10782523] cysteine-type endopeptidase activity of activated TLR4:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane]
(output)	[Reaction:R-GGA-2562541] TLR4-induced ripoptosome assembly
(inferredTo)	[Complex:R-HSA-2562542] activated TLR4:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane]

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