Reactome | DNA Damage/Telomere Stress Induced Senescence

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DNA Damage/Telomere Stress Induced Senescence Show undefined attributes

created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10825135
displayName	DNA Damage/Telomere Stress Induced Senescence
eventOf	[Pathway:R-GGA-2559583] Cellular Senescence - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-GGA-3785768] MRN complex binds DNA double strand breaks - Gallus gallus [Reaction:R-GGA-5682020] MRN complex binds shortened telomeres - Gallus gallus [Reaction:R-GGA-5693612] MRN complex bound to DNA ends recruits ATM - Gallus gallus [Reaction:R-GGA-5682044] KAT5 acetylates ATM at DNA DSBs - Gallus gallus [Reaction:R-GGA-5693540] MRN activates ATM - Gallus gallus [Reaction:R-GGA-5682018] MRN complex bound to shortened telomeres recruits ATM - Gallus gallus [Reaction:R-GGA-6792712] KAT5 acetylates ATM at shortened telomeres - Gallus gallus [Reaction:R-GGA-5682026] MRN bound to shortened telomeres activates ATM - Gallus gallus [Reaction:R-GGA-187934] Inactivation of Cyclin A:Cdk2 complexes by p27/p21 - Gallus gallus [Reaction:R-GGA-69562] Inactivation of Cyclin E:Cdk2 complexes by p27/p21 - Gallus gallus [Pathway:R-GGA-2559584] Formation of Senescence-Associated Heterochromatin Foci (SAHF) - Gallus gallus
inferredFrom	[Pathway:R-HSA-2559586] DNA Damage/Telomere Stress Induced Senescence - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	3
name	DNA Damage/Telomere Stress Induced Senescence
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49591] Gallus gallus
stId	R-GGA-2559586
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-2559583] Cellular Senescence
(hasEncapsulatedEvent)	[Pathway:R-GGA-157579] Telomere Maintenance [Pathway:R-GGA-2559580] Oxidative Stress Induced Senescence [Pathway:R-GGA-2559582] Senescence-Associated Secretory Phenotype (SASP) [Pathway:R-GGA-2559585] Oncogene Induced Senescence
(inferredTo)	[Pathway:R-HSA-2559586] DNA Damage/Telomere Stress Induced Senescence

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