Reactome | Separation of Sister Chromatids

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Separation of Sister Chromatids Show undefined attributes

compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10826043
displayName	Separation of Sister Chromatids
eventOf	[Pathway:R-GGA-68882] Mitotic Anaphase - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:161319] mitotic sister chromatid separation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-GGA-174121] Association of Securin with Cdc20:APC/C complex - Gallus gallus [Reaction:R-GGA-174144] Ubiquitination of Securin by phospho-APC/C:Cdc20 complex - Gallus gallus [BlackBoxEvent:R-GGA-174202] Degradation of multiubiquitinated Securin - Gallus gallus [Reaction:R-GGA-2467798] PTTG1 (Securin) sequesters ESPL1 (Separase) - Gallus gallus [Reaction:R-GGA-2467775] Autocleavage of ESPL1 (Separase) - Gallus gallus [Reaction:R-GGA-2467809] ESPL1 (Separase) cleaves centromeric cohesin - Gallus gallus [Reaction:R-GGA-2545203] Deacetylation of cleaved cohesin - Gallus gallus
inferredFrom	[Pathway:R-HSA-2467813] Separation of Sister Chromatids - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Separation of Sister Chromatids
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49591] Gallus gallus
stId	R-GGA-2467813
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-68882] Mitotic Anaphase
(inferredTo)	[Pathway:R-HSA-2467813] Separation of Sister Chromatids