Reactome | RDH12 reduces atRAL to atROL

Schema > Reaction > Entries

RDH12 reduces atRAL to atROL Show undefined attributes

catalystActivity	[CatalystActivity:10781890] all-trans-retinol dehydrogenase (NADP+) activity of RDH12 [photoreceptor inner segment membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:2473609] photoreceptor inner segment membrane
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10781892
displayName	RDH12 reduces atRAL to atROL
eventOf	[Pathway:R-GGA-2453902] The canonical retinoid cycle in rods (twilight vision) - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-GGA-2465938] RBP3 regulates atROL taken up by Muller cells - Gallus gallus [BlackBoxEvent:R-GGA-2464809] RBP3 regulates the transport of atROL from ROS to RPE - Gallus gallus
inferredFrom	[Reaction:R-HSA-2464822] RDH12 reduces atRAL to atROL - Homo sapiens
input	[SimpleEntity:R-ALL-975622] atRAL [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29364] NADPH [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	RDH12 reduces atRAL to atROL
output	[SimpleEntity:R-ALL-2473615] atROL [cytosol] [SimpleEntity:R-ALL-29366] NADP+ [cytosol]
precedingEvent	[Reaction:R-GGA-1467466] ABCA4 mediates atRAL transport - Gallus gallus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-2464822
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-2453902] The canonical retinoid cycle in rods (twilight vision)
(precedingEvent)	[BlackBoxEvent:R-GGA-2465938] RBP3 regulates atROL taken up by Muller cells [BlackBoxEvent:R-GGA-2464809] RBP3 regulates the transport of atROL from ROS to RPE
(inferredTo)	[Reaction:R-HSA-2464822] RDH12 reduces atRAL to atROL