Reactome | ASA- acetylates PTGS2

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ASA- acetylates PTGS2 Show undefined attributes

category	transition
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10781119
displayName	ASA- acetylates PTGS2
eventOf	[Pathway:R-GGA-2162123] Synthesis of Prostaglandins (PG) and Thromboxanes (TX) - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-GGA-9027627] Ac-PTGS2 dimer oxidises DHA to 17-HDHA (macrophages) - Gallus gallus [Reaction:R-GGA-9020261] Ac-PTGS2 dimer oxidises DHA to 17(R)-Hp-DHA - Gallus gallus [Reaction:R-GGA-2161951] Arachidonate is oxidised to 15R-HETE by Acetyl-PTGS2 - Gallus gallus [Reaction:R-GGA-9018880] Ac-PTGS2 dimer oxidises EPA to 18(R)-HpEPE or 18(S)-HpEPE - Gallus gallus
inferredFrom	[Reaction:R-HSA-2314686] ASA- acetylates PTGS2 - Homo sapiens
input	[ChemicalDrug:R-ALL-2314693] ASA- [cytosol] [Complex:R-GGA-140491] PTGS2 dimer [endoplasmic reticulum membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	ASA- acetylates PTGS2
output	[Complex:R-GGA-2314687] Ac-PTGS2 dimer [endoplasmic reticulum membrane] [SimpleEntity:R-ALL-2314690] ST [cytosol]
precedingEvent	[Reaction:R-GGA-9645220] SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol - Gallus gallus [Reaction:R-GGA-9749607] SLCO2B1-1 transports ASA- from extracellular region to cytosol of GI cells - Gallus gallus [Reaction:R-GGA-9749583] SLC22A7 transports ASA-,ST from extracellular region to cytosol of hepatocytes - Gallus gallus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-2314686
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(precedingEvent)	[Reaction:R-GGA-9027627] Ac-PTGS2 dimer oxidises DHA to 17-HDHA (macrophages) [Reaction:R-GGA-9020261] Ac-PTGS2 dimer oxidises DHA to 17(R)-Hp-DHA [Reaction:R-GGA-2161951] Arachidonate is oxidised to 15R-HETE by Acetyl-PTGS2 [Reaction:R-GGA-9018880] Ac-PTGS2 dimer oxidises EPA to 18(R)-HpEPE or 18(S)-HpEPE
(hasEvent)	[Pathway:R-GGA-2162123] Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
(inferredTo)	[Reaction:R-HSA-2314686] ASA- acetylates PTGS2

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