Reactome | TRAF3 binds TICAM1:activated TLR4 complex

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TRAF3 binds TICAM1:activated TLR4 complex Show undefined attributes

category	binding
compartment	[Compartment:74700] endosome membrane [Compartment:70101] cytosol
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10780782
displayName	TRAF3 binds TICAM1:activated TLR4 complex
eventOf	[Pathway:R-GGA-936964] Activation of IRF3, IRF7 mediated by TBK1, IKK? (IKBKE) - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-GGA-2213017] Auto-ubiquitination of TRAF3 - Gallus gallus
inferredFrom	[Reaction:R-HSA-2201338] TRAF3 binds TICAM1:activated TLR4 complex - Homo sapiens
input	[Complex:R-GGA-166172] TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] 2 × [EntityWithAccessionedSequence:R-GGA-914241] TRAF3 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	TRAF3 binds TICAM1:activated TLR4 complex TRAF3 binds TRIF:activated TLR4 complex TRAF3 binds TICAM1:TRAM:TLR4:LY96:LPS:CD14
output	[Complex:R-GGA-2201339] TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane]
precedingEvent	[Reaction:R-GGA-166175] TRAM:TLR4:LY96:LPS:CD14 recruits TRIF (TICAM1) - Gallus gallus
regulatedBy	[NegativeRegulation:10742623] Negative regulation by 'SARM:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-2201338
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-936964] Activation of IRF3, IRF7 mediated by TBK1, IKK? (IKBKE)
(precedingEvent)	[BlackBoxEvent:R-GGA-2213017] Auto-ubiquitination of TRAF3
(inferredTo)	[Reaction:R-HSA-2201338] TRAF3 binds TICAM1:activated TLR4 complex

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