Reactome | NOTCH2 intracellular domain regulates transcription

Schema > Pathway > Entries

compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10827465
displayName	NOTCH2 intracellular domain regulates transcription
eventOf	[Pathway:R-GGA-1980145] Signaling by NOTCH2 - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-GGA-2197588] NICD2 binds RBPJ and MAML in the nucleus - Gallus gallus
inferredFrom	[Pathway:R-HSA-2197563] NOTCH2 intracellular domain regulates transcription - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	NOTCH2 intracellular domain regulates transcription
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49591] Gallus gallus
stId	R-GGA-2197563
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-GGA-1980145] Signaling by NOTCH2
(inferredTo)	[Pathway:R-HSA-2197563] NOTCH2 intracellular domain regulates transcription

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