Reactome | C5b:C6:C7:C8 and C9 bind to form membrane attack complex (MAC)

Schema > Reaction > Entries

C5b:C6:C7:C8 and C9 bind to form membrane attack complex (MAC) Show undefined attributes

authored	[InstanceEdit:2869458] Shamovsky, V, 2012-12-20
category	binding
compartment	[Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:2132098] Shamovsky, V, 2012-02-21
dbId	2132221
displayName	C5b:C6:C7:C8 and C9 bind to form membrane attack complex (MAC)
edited	[InstanceEdit:5149549] Shamovsky, V, 2013-11-19
eventOf	[Pathway:R-GGA-2132267] Formation of membrane attack complex (MAC) - Gallus gallus
inferredFrom	[Reaction:R-HSA-173725] C9 binds C5b:C6:C7:C8 - Homo sapiens
input	[Complex:R-GGA-2132050] C5b:C6:C7:C8 [plasma membrane] 12 × [GenomeEncodedEntity:R-GGA-2132070] C9 [extracellular region]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:2109533] Molecular organization of C9 within the membrane attack complex of complement. Induction of circular C9 polymerization by the C5b-8 assembly [LiteratureReference:2173551] The role of C9 in complement-mediated killing of Neisseria [LiteratureReference:2173472] High incidence of complement C9 deficiency in Koreans [LiteratureReference:2173481] High-incidence of C9 deficiency throughout Japan: there are no significant differences in incidence among eight areas of Japan [LiteratureReference:2173499] Inherited deficiency of the ninth component of complement in man [LiteratureReference:2132291] Cloning of the sixth complement component and, spatial and temporal expression profile of MAC structural and regulatory genes in chicken [LiteratureReference:2173531] Molecular cloning, promoter analysis and induced expression of the complement component C9 gene in the grass carp Ctenopharyngodon idella [LiteratureReference:2173451] Expression of complement components coincides with early patterning and organogenesis in Xenopus laevis
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	C5b:C6:C7:C8 and C9 bind to form membrane attack complex (MAC)
output	[Complex:R-GGA-2132123] MAC [plasma membrane]
precedingEvent	[Reaction:R-GGA-2132094] C8 binds to C5b:C6:C7 complement complex - Gallus gallus
regulatedBy	[NegativeRegulation:R-GGA-2132134] Negative regulation by 'VTN:C5b-C9 [extracellular region]' [NegativeRegulation:R-GGA-2132207] Negative regulation by 'CD59 [plasma membrane]'
releaseDate	2014-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2562608] D'Eustachio, P, 2012-11-06 [InstanceEdit:3006589] Jupe, S, 2013-01-31
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-2132221
summation	[Summation:2173416] Complement C9 is the final component incorporated into the m...
updateTrackers	[UpdateTracker:9785972] Update Tracker - [Reaction:2132221] C5b:C6:C7:C8 and C9 bind to form membrane attack complex (MAC) - v50:[add_removeRegulator]

Referrals

(updatedInstance)	[UpdateTracker:9785972] Update Tracker - [Reaction:2132221] C5b:C6:C7:C8 and C9 bind to form membrane attack complex (MAC) - v50:[add_removeRegulator]
(hasEvent)	[Pathway:R-GGA-2132267] Formation of membrane attack complex (MAC)
(inferredTo)	[Reaction:R-HSA-173725] C9 binds C5b:C6:C7:C8