Reactome | Opsonization with C3b or C4b

Schema > BlackBoxEvent > Entries

Opsonization with C3b or C4b Show undefined attributes

authored	[InstanceEdit:2869458] Shamovsky, V, 2012-12-20
category	omitted
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:2132098] Shamovsky, V, 2012-02-21
dbId	2132201
displayName	Opsonization with C3b or C4b
edited	[InstanceEdit:5149549] Shamovsky, V, 2013-11-19
eventOf	[Pathway:R-GGA-2132285] Complement Cascade - Gallus gallus
inferredFrom	[Reaction:R-HSA-981539] C3b binds to cell surface - Homo sapiens [Reaction:R-HSA-981713] C4b binds to cell surface - Homo sapiens
input	[DefinedSet:R-GGA-2132216] C3b/C4b [extracellular region] [OtherEntity:R-ALL-2132109] Cell-surface carbohydrates [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:2314656] Fibronectin-enhanced phagocytosis of an alternative pathway activator by human culture-derived macrophages is mediated by the C4b/C3b complement receptor (CR1) [LiteratureReference:2314649] Kinetic studies of phagocytosis. III. The complement-dependent opsonic and anti-opsonic effects of normal and sle sera [LiteratureReference:2314676] The binding of immune complexes by the erythrocyte complement receptor 1 (CR1) [LiteratureReference:2314663] Complement-opsonized IgG antibody/dsDNA immune complexes bind to CR1 clusters on isolated human erythrocytes [LiteratureReference:2314654] Mechanism of transfer of immune complexes from red blood cell CR1 to monocytes
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Opsonization with C3b or C4b
output	[DefinedSet:R-GGA-2132152] C3b/C4b [plasma membrane]
precedingEvent	[Reaction:R-GGA-2132085] Cleavage of C3 by surface-bound C3 convertases - Gallus gallus
releaseDate	2014-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2562608] D'Eustachio, P, 2012-11-06 [InstanceEdit:3006589] Jupe, S, 2013-01-31
schemaClass	BlackBoxEvent
species	[Species:49591] Gallus gallus
stId	R-GGA-2132201
summation	[Summation:2314463] C4b and C3b are opsonins, which are able to bind covalently ...

Referrals

(hasEvent)	[Pathway:R-GGA-2132285] Complement Cascade
(inferredTo)	[Reaction:R-HSA-981713] C4b binds to cell surface [Reaction:R-HSA-981539] C3b binds to cell surface