Reactome | AKT-mediated inactivation of FOXO1A

Schema > Pathway > Entries

created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10826491
displayName	AKT-mediated inactivation of FOXO1A
eventOf	[Pathway:R-GGA-210745] Regulation of gene expression in beta cells - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:1042974] regulation of type B pancreatic cell development
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-GGA-211164] AKT phosphorylates FOXO1A - Gallus gallus [Reaction:R-GGA-211178] Phosphorylated FOXO1A is excluded from the nucleus - Gallus gallus
inferredFrom	[Pathway:R-HSA-211163] AKT-mediated inactivation of FOXO1A - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	AKT-mediated inactivation of FOXO1A
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49591] Gallus gallus
stId	R-GGA-211163
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-GGA-210745] Regulation of gene expression in beta cells
(inferredTo)	[Pathway:R-HSA-211163] AKT-mediated inactivation of FOXO1A

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